Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

Global sensitivity analysis of cell signaling transduction networks based on latin hypercube sampling method

Jia, J.F. and Yue, H. and Liu, T.Y. and Wang, H. (2007) Global sensitivity analysis of cell signaling transduction networks based on latin hypercube sampling method. In: The 1st International Conference on Bioinformatics and Biomedical Engineering, 2007-07-06 - 2007-07-08.

Full text not available in this repository. Request a copy from the Strathclyde author


The dynamic behavior of a cell model is affected by its structural complexity and parametric uncertainties. Two important issues in systems biology are how to quantitatively determine the relationship between system behaviors and parameter variations, and how to study the interactions between parameters. Using an NF-κB signaling pathway model as an example, and assuming that the parameters of this model are independent of each other and obey the identical uniform distribution in the range of variations, the global sensitivity analysis on the system output of NF-κB in the nucleus with respect to parameters is studied by means of the Latin hypercube sampling method. Simulation results demonstrate that the oscillation behavior of the concentration of NF-κB in the nucleus is sensitive to 6 key rate constants, which relates to reactions of IκBα mRNA degradation, IκBα inducible mRNA synthesis, IKK adaption, constitutive IκBα mRNA translation, IKK-IκBα NF-κB association, and IκBβ mRNA degradation, respectively.