Mains, Jenifer and Urquhart, Andrew and Wilson, Clive (2012) A pharmacokinetic study of a combination of beta adrenoreceptor antagonists – In the isolated perfused ovine eye. European Journal of Pharmaceutics and Biopharmaceutics, 80. pp. 393-401. ISSN 0939-6411Full text not available in this repository. (Request a copy from the Strathclyde author)
The treatment of posterior eye diseases, such as diabetic retinopathy and age-related macular degeneration, is of growing interest as the number of people affected by these conditions continues to rise. This study utilises the methods of cassette dosing and the perfused ovine eye model – to reduce animal usage and therefore animal time – to show that for a series of beta adrenoreceptor antagonists, lipophilicity is a key physicochemical property that governs drug distribution within the eye. Following intravitreal injection, lipophilic beta adrenoreceptor antagonists penetrate to the posterior eye, where they bind to the choroid and reside in the retina at greater concentrations than more hydrophilic beta adrenoreceptor antagonists, which preferentially penetrate to the anterior eye.
|Keywords:||ovine eye , pharmacokinetics, biopharmaceutics, adrenoreceptor antagonists, Therapeutics. Pharmacology|
|Subjects:||Medicine > Therapeutics. Pharmacology|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
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|Depositing user:||Pure Administrator|
|Date Deposited:||20 Dec 2011 11:58|
|Last modified:||12 Jun 2013 16:03|
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