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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Metabonomics as a clinical tool of analysis : LC-MS approaches

Alzweiri, Muhammed and Watson, David G. and Parkinson, John A. (2013) Metabonomics as a clinical tool of analysis : LC-MS approaches. Journal of Liquid Chromatography and Related Technologies, 36 (1). pp. 94-115.

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Abstract

Metabolic differences between test and control groups (i.e. metabonomics) are routinely accomplished by using multivariate analysis for data obtained commonly from NMR, GC-MS and LC-MS. Multivariate analysis (e.g. principal component analysis PCA) is commonly used to extract potential metabolites responsible for clinical observations. Metabonomics applied to the clinical field is challenging because the physiological variabilities like gender, age, race…etc might govern the cluster pattern obtained by multivariate analysis instead of the tested differences. This review focuses on the challenges facing the clinical applications of metabonomics and introduces their possible solutions as mentioned in the literature.