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The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle

Mccarron, John and Bradley, Karen and Macmillan, Debbi and Chalmers, Susan and Muir, Thomas C. (2004) The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle. News in Physiological Sciences, 19. pp. 138-147. ISSN 0886-1714

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Abstract

The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky," the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs) propagates as calcium waves; IP(3)Rs alone account for wave propagation.