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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle

Mccarron, John and Bradley, Karen and Macmillan, Debbi and Chalmers, Susan and Muir, Thomas C. (2004) The sarcoplasmic reticulum, Ca2+ trapping, and wave mechanisms in smooth muscle. News in Physiological Sciences, 19. pp. 138-147. ISSN 0886-1714

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Abstract

The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky," the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs) propagates as calcium waves; IP(3)Rs alone account for wave propagation.