Xu, Dan and Saeed, Amir and Wang, Yili and Seidel, Veronique and Sandstrome, Gunnar and Yu, Jun (2011) Natural products modulate Shigella–host-cell interaction. Journal of Medical Microbiology, 60 (11). pp. 1626-1632. ISSN 0022-2615Full text not available in this repository. (Request a copy from the Strathclyde author)
This study focused on identifying possible new options derived from natural sources for the treatment of bacterial infections. Several natural products were investigated for their potential in modulating Shigella-host-cell interactions. The proliferation of Shigella sonnei was effectively inhibited inside HEp-2 cells in the presence of 4-methoxycinnamic acid and propolin D. Propolin D also significantly reduced the apoptosis of infected macrophage-like U937 cells and moderately reduced the secretion of interleukin (IL)-1β and IL-18, which probably resulted from the inhibition of invasion plasmid antigen B secretion by this compound. Further characterization showed that propolin D did not prevent escape of Shigella from phagocytic vacuoles, as evidenced by actin-based motility and by the fact that addition of chloroquine did not further reduce the number of intracellular c.f.u. The role of propolin D in modulating autophagy could not be established under the experimental conditions used. As these compounds had no direct anti-Shigella activity in vitro, it was concluded that these compounds modulated Shigella-host-cell interactions by targeting yet-to-be defined mechanisms that provide benefits to host cells.
|Keywords:||natual products, shigella sonnei, host interation, Therapeutics. Pharmacology, Microbiology, Microbiology (medical)|
|Subjects:||Medicine > Therapeutics. Pharmacology|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||18 Nov 2011 05:22|
|Last modified:||27 Apr 2016 17:46|