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Pre-operative sildenafil and pulmonary endothelial-related complications following cardiopulmonary bypass : a randomised trial in children undergoing cardiac surgery*

Vassalos, A and Peng, E and Young, D and Walker, S and Pollock, J and Macarthur, K and Lyall, F and Danton, M H D (2011) Pre-operative sildenafil and pulmonary endothelial-related complications following cardiopulmonary bypass : a randomised trial in children undergoing cardiac surgery*. Anaesthesia, 66 (6). pp. 472-80.

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Abstract

In a randomised trial, we compared the effects of oral sildenafil (0.5 mg.kg(-1) ) and placebo, administered the day before cardiac surgery, in 24 children. In sildenafil vs placebo patients, pre-cardiopulmonary bypass median (IQR [range]) cyclic-guanosine-monophosphate was not significantly different (29.9 (2.1-208.1 [0.5-391.5]) vs 5.2 (0.3-54.6 [0-628.9]) pmol.ml(-1) , respectively). Post-cardiopulmonary bypass, nitrate/nitrite levels were also not significantly different (0.7 (0-8.0 [0-142.8]) vs 0 (0-2.7 [0-52.7]) μM, respectively). Postoperatively, mean (SD) pulmonary vascular resistance (2.64 (2.28) vs 1.90 (1.12) WU.m(-2) , respectively and oxygenation index (5.29 (4.60) vs 3.38 (2.54), respectively) remained unchanged, whilst oxygen delivery (57.18 (21.24) vs 74.13 (35.46) ml.min(-1) .m(-2) , respectively) and bi-ventricular systolic function (left ventricle 3.78 (0.94) vs 4.55 (1.08) cm.s(-1) , respectively; p = 0.002; right ventricle 6.93 (1.47) vs 8.09 (2.25) cm.s(-1) , respectively; p

Item type: Article
ID code: 35945
Notes: © 2011 The Authors. Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland.
Keywords: oral sildenafil , placebo, post-cardiopulmonary bypass, postoperative, pre-operative , pulmonary vascular resistance, Pharmacy and materia medica, Probabilities. Mathematical statistics, Anesthesiology and Pain Medicine
Subjects: Medicine > Pharmacy and materia medica
Science > Mathematics > Probabilities. Mathematical statistics
Department: Faculty of Science > Mathematics and Statistics
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Pure Administrator
Date Deposited: 16 Nov 2011 16:45
Last modified: 27 Mar 2014 09:23
URI: http://strathprints.strath.ac.uk/id/eprint/35945

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