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In vivo imaging of drug delivery systems in the gastrointestinal tract

Weitschies, Werner and Wilson, Clive (2011) In vivo imaging of drug delivery systems in the gastrointestinal tract. International Journal of Pharmaceutics, 417 (1-2). pp. 216-226. ISSN 0378-5173

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Abstract

An essential basis for the understanding of the complex interplay between oral drugdeliverysystems and gastrointestinal physiology is the ability to relate deposition of the dosage form to the plasma concentration time profile. The pharmaceutical scientist requires an array of methods that provide information on formulation disposition without influencing the physiological process, commonly termed “non-invasive” imaging modalities. In this paper, a short historical view on the suitability of different imaging modalities for the investigation of the fate of drugdeliverysystems in the GI tract is given. The focus of the review is the presentation of currently mostly used methodologies scintigraphy, magnetic tracking techniques like magnetic marker monitoring (MMM), magnetic moment imaging (MMI), AC biosusceptometry (ACB) and magnetic resonance imaging and the discussion of their strengths and weaknesses.

Item type: Article
ID code: 35875
Keywords: in vivoimaging , drug delivery systems, gamma scintigraphy, magnetic marker monitoring , magnetic moment imaging, magnetic resonance imaging , magnetic pill tracking, AC biosusceptometry, Therapeutics. Pharmacology, Pharmaceutical Science
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Pure Administrator
Date Deposited: 15 Nov 2011 05:19
Last modified: 27 Mar 2014 09:50
URI: http://strathprints.strath.ac.uk/id/eprint/35875

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