Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

In vivo imaging of drug delivery systems in the gastrointestinal tract

Weitschies, Werner and Wilson, Clive (2011) In vivo imaging of drug delivery systems in the gastrointestinal tract. International Journal of Pharmaceutics, 417 (1-2). pp. 216-226. ISSN 0378-5173

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

An essential basis for the understanding of the complex interplay between oral drugdeliverysystems and gastrointestinal physiology is the ability to relate deposition of the dosage form to the plasma concentration time profile. The pharmaceutical scientist requires an array of methods that provide information on formulation disposition without influencing the physiological process, commonly termed “non-invasive” imaging modalities. In this paper, a short historical view on the suitability of different imaging modalities for the investigation of the fate of drugdeliverysystems in the GI tract is given. The focus of the review is the presentation of currently mostly used methodologies scintigraphy, magnetic tracking techniques like magnetic marker monitoring (MMM), magnetic moment imaging (MMI), AC biosusceptometry (ACB) and magnetic resonance imaging and the discussion of their strengths and weaknesses.