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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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First organophosphorus radical-mediated cyclisations to afford medium-sized rings : eight-membered lactones and seven- and eight-membered lactams

Lang, Stuart and Corr, Michael and Muir, Neil and Khan, Tanweer and Schonebeck, Franziska and Murphy, John and Payne, Andrew and Williams, Andrew (2005) First organophosphorus radical-mediated cyclisations to afford medium-sized rings : eight-membered lactones and seven- and eight-membered lactams. Tetrahedron Letters, 46 (23). pp. 4027-4030. ISSN 0040-4039

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Abstract

The phosphorus based radical precursors N-ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO) are efficient reagents for carrying out the formation of seven- and eight-membered rings. Esters and amides were successfully converted into the corresponding eight-membered lactones and seven- and eight-membered lactams in good to excellent yields.