Lang, Stuart and Corr, Michael and Muir, Neil and Khan, Tanweer and Schonebeck, Franziska and Murphy, John and Payne, Andrew and Williams, Andrew (2005) First organophosphorus radical-mediated cyclisations to afford medium-sized rings : eight-membered lactones and seven- and eight-membered lactams. Tetrahedron Letters, 46 (23). pp. 4027-4030. ISSN 0040-4039Full text not available in this repository. (Request a copy from the Strathclyde author)
The phosphorus based radical precursors N-ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO) are efficient reagents for carrying out the formation of seven- and eight-membered rings. Esters and amides were successfully converted into the corresponding eight-membered lactones and seven- and eight-membered lactams in good to excellent yields.
|Keywords:||radical, phosphorus, DEPO, EPHP, cyclisation, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery|
|Subjects:||Science > Chemistry|
|Department:||Faculty of Science > Pure and Applied Chemistry|
|Depositing user:||Pure Administrator|
|Date Deposited:||21 Nov 2011 16:15|
|Last modified:||04 May 2016 20:51|