Lang, Stuart and Corr, Michael and Muir, Neil and Khan, Tanweer and Schonebeck, Franziska and Murphy, John and Payne, Andrew and Williams, Andrew (2005) First organophosphorus radical-mediated cyclisations to afford medium-sized rings : eight-membered lactones and seven- and eight-membered lactams. Tetrahedron Letters, 46 (23). pp. 4027-4030. ISSN 0040-4039
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1016/j.tetlet.2005.04.032
Abstract
The phosphorus based radical precursors N-ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO) are efficient reagents for carrying out the formation of seven- and eight-membered rings. Esters and amides were successfully converted into the corresponding eight-membered lactones and seven- and eight-membered lactams in good to excellent yields.
| Item type: | Article |
|---|---|
| ID code: | 35775 |
| Keywords: | radical, phosphorus, DEPO, EPHP, cyclisation, Chemistry |
| Subjects: | Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 21 Nov 2011 16:15 |
| Last modified: | 12 Mar 2012 11:40 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/35775 |
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