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E- and Z-Stereoselectivity in the preparation of enamides from glycidyl sulfonamides and carbamates

Brown, Jack A and Chudasama, Vijay and Giles, Melvyn E and Gill, Duncan M and Keegan, Philip S and Kerr, William J and Munday, Rachel H and Griffin, Karen and Watts, Andrew (2012) E- and Z-Stereoselectivity in the preparation of enamides from glycidyl sulfonamides and carbamates. Organic and Biomolecular Chemistry, 10 (3). pp. 509-511. ISSN 1477-0520

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    Abstract

    Treatment of glycidyl sulfonamides with LDA delivers the corresponding enesulfonamide with good selectivity for the E-isomer, whereas the corresponding carbamates exhibit selectivity for the Z-enecarbamate. An E1cB elimination mechanism proceeding from a substrate–base chelate complex is advanced as rationalisation of the latter set of Z-selective outcomes.

    Item type: Article
    ID code: 35721
    Keywords: enamides , glycidyl sulfonamides , carbamates, Chemistry, Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry
    Subjects: Science > Chemistry
    Department: Faculty of Science > Pure and Applied Chemistry
    Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 09 Nov 2011 12:08
    Last modified: 27 Mar 2014 22:06
    URI: http://strathprints.strath.ac.uk/id/eprint/35721

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