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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Inversion of spectroscopic measurements for extracting particle size distribution

Pariset, Carlo and Thennadil, Suresh (2009) Inversion of spectroscopic measurements for extracting particle size distribution. In: 6th International Multi-Conference on Systems, Signals & Devices, 2009-03-23 - 2009-03-26.

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Abstract

Information on the particle size distribution (PSD) of a particulate system is contained in the turbidity measurements. To obtain the PSD from such measurements, the inversion of a Fredholm integral of the first kind is required. To solve this ill-posed problem Tikhonov regularization technique can be used. The central issue in every regularization problem is the choice of an effective regularization parameter and to perform such a choice in a complete automatic way without any inputs from the operator. In this work the PSD of polystyrene spheres in water are estimated from turbidity measurements using a CARY5000 spectrometer. Two formulations for the search of the regularization parameter based on cross-validation are compared and a two-step process integrating the two formulations is investigated.