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Insect repellent [correction of repellant] interactions : sunscreens enhance DEET (N,N-diethyl-m-toluamide) absorption

Ross, Edward A and Savage, Kathleen A and Utley, Luke J and Tebbett, Ian R (2004) Insect repellent [correction of repellant] interactions : sunscreens enhance DEET (N,N-diethyl-m-toluamide) absorption. Drug Metabolism and Disposition, 32 (8). pp. 783-785. ISSN 0090-9556

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Abstract

Toxicology studies are typically performed on single compounds, which we hypothesized would miss adverse synergies from chemical mixtures. This hypothesis was tested using an insect repellant and sunscreens because both groups include known permeation enhancers, with prior pediatric reports of toxicity from highly concentrated DEET (N,N-diethyl-m-toluamide). Using real-time mass spectroscopy in a hairless mouse skin model, we confirmed substantial penetration of a 20% DEET standard. Despite a lower (10%) DEET content, a commercially marketed sunscreen formulation had a 6-fold more rapid detection (5 versus 30 min) and 3.4-fold greater penetration at steady state. We also tested the efficacy of DEET microemulsion products and confirmed that one successfully slowed the onset of absorption, but not the steady-state permeation. Risks from mixtures of potential toxins are worthy of routine testing, which can be accomplished by simple assays, and are of utmost importance for pediatric applications.

Item type: Article
ID code: 35515
Keywords: animals, DEET, drug synergism, insect repellents, mice, hairless mice, skin, skin absorption, sunscreening agents, Chemistry, Pharmaceutical Science, Pharmacology
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 07 Nov 2011 16:19
    Last modified: 05 Sep 2014 13:17
    URI: http://strathprints.strath.ac.uk/id/eprint/35515

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