Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Phase sensitivity analysis for biological oscillatory systems

Lu, Baoyun and Yue, Hong (2010) Phase sensitivity analysis for biological oscillatory systems. In: 29th Chinese Control Conference, 2010-07-29 - 2010-07-31, Beijing.

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Oscillation is one of the most important nonlinear behaviors which is widely observed in living cells. There has been a growing experimental and computational evidence of oscillations in biological systems, which brings an increasing interest in understanding how such oscillations occur and what are the main factors in controlling these oscillations. Sensitivity analysis is a powerful tool in investigating the impact of parameter variations on the change of oscillation behaviors quantitatively. For an oscillatory system, the phase sensitivity analysis is a challenging problem in formulation and computation. In this work, a systematic phase sensitivity analysis method is proposed by analyzing the relationship between the phase sensitivity and the state sensitivity. A new concept of basal state sensitivity is proposed based on which the phase sensitivity can be derived. The proposed algorithm is easy to implement and interpret for limit cycle oscillatory systems. It is applied to a circadian rhythm mathematical model. The simulation result shows the efficiency of this approach and also highlights the importance of investigating sensitivity analysis using different features of a limit cycle.

Item type: Conference or Workshop Item (Paper)
ID code: 35272
Keywords: ohase sensitivity analysis, biological oscillatory systems , oscillatory systems, Electrical engineering. Electronics Nuclear engineering
Subjects: Technology > Electrical engineering. Electronics Nuclear engineering
Department: Faculty of Engineering > Electronic and Electrical Engineering
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 26 Oct 2011 16:49
    Last modified: 17 Jul 2013 16:18
    URI: http://strathprints.strath.ac.uk/id/eprint/35272

    Actions (login required)

    View Item