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Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate

Johnston, Andrea and Florence, Alastair J. and Kennedy, Alan R. (2006) Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate. Acta Crystallographica Section E: Structure Reports, 62. O5169-O5171. ISSN 1600-5368

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Abstract

Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.

Item type: Article
ID code: 35247
Keywords: hydrochlorothiazide , disolvates, crystallization, Chemistry, Therapeutics. Pharmacology, Materials Science(all), Chemistry(all), Condensed Matter Physics
Subjects: Science > Chemistry
Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 02 Nov 2011 12:28
    Last modified: 05 Sep 2014 12:55
    URI: http://strathprints.strath.ac.uk/id/eprint/35247

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