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Hydrochlorothiazide N,N-dimethylformamide solvate

Johnston, A and Florence, A J and Kennedy, A R (2006) Hydrochlorothiazide N,N-dimethylformamide solvate. Acta Crystallographica Section E: Structure Reports, 62. O1730-O1732. ISSN 1600-5368

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Abstract

Hydrochlorothiazide forms a 1: 1 solvate with N,N-dimethylformamide (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4benzothiadiazine- 7-sulfonamide-1,1-dioxide dimethylformamide solvate), C7H8ClN3O4S2 (.) C3H7NO. The compound crystallizes with two molecules of hydrochlorothiazide and two solvent molecules in the asymmetric unit and displays an extensive hydrogen-bonding network.