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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

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A direct derivative method for estimating kinetic parameters of biological networks

Jia, Jianfang and Yue, Hong (2011) A direct derivative method for estimating kinetic parameters of biological networks. In: 30th Chinese Control Conference, 2011-07-22 - 2011-07-24.

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Abstract

Challenged by strong nonlinearity of cellular network models, large uncertainty in model parameters, and noisy experimental data, a new parameter estimation algorithm, direct derivative method (DDM), is presented in which the measurement data are firstly fitted with smoothing splines, and then the first-order derivative of state variables are evaluated and substituted into the model. Thus, a dynamic optimization problem is converted into a linear or nonlinear regression problem. There is no need to solve ordinary differential equations of the system models iteratively, the computational complexity is therefore reduced to a large extent. Taking the IκBα-NF-κB signal transduction pathways as an example, unknown parameters are estimated effectively using the proposed DDM algorithm, and various factors that affect the results are investigated.