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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Differential effect of finasteride on the tissue androgen concentrations in benign prostatic hyperplasia

Habib, F K and Ross, M and Tate, R and Chisholm, G D (1997) Differential effect of finasteride on the tissue androgen concentrations in benign prostatic hyperplasia. Clinical Endocrinology, 46 (2). pp. 137-44. ISSN 0300-0664

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Abstract

The 5 alpha-reductase inhibitor, finasteride, provides a logical medical treatment for benign prostatic hyperplasia (BPH). However, the effects of chronic finasteride treatment on prostatic androgen levels, 5 alpha-reductase activity and tissue prostatic specific antigen (PSA) have not been studied. We have examined prostate tissue androgen concentrations and 5 alpha-reductase activity of the gland in men with BPH treated with the drug for 3 months.