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Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology

Beattie, James and McIntosh, Lisa and van der Walle, Christopher F (2010) Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology. Journal of Cellular Physiology, 224 (3). pp. 605-611.

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Abstract

The biology of cross-talk between activated growth factor receptors and cell-surface integrins is an area which has attracted much interest in recent years (Schwartz and Ginsberg, 2002). This review discusses the relationship between the insulin-like growth factor (IGF) axis and cell-surface integrin receptors in the regulation of various aspects of cell physiology. Key to these interactions are signals transmitted between integrins and the IGF-I receptor (IGF-IR) when either or both are bound to their cognate ligands and we will review the current state of knowledge in this area. The IGF axis comprises many molecular components and we will also discuss the potential role of these species in cross-talk with the integrin receptor. With respect to integrin ligands, we will mainly focus on the well-characterized interactions of the two extracellular matrix (ECM) glycoproteins fibronectin (FN) and vitronectin (VN) with cell-surface ligands, and, how this affects activity through the IGF axis. However, we will also highlight the importance of other integrin activation mechanisms and their impact on IGF activity.

Item type: Article
ID code: 35158
Notes: (c) 2010 Wiley-Liss, Inc.
Keywords: cell physiological phenomena, extracellular matrix, fibronectins, insulin-like growth factor binding proteins, insulin-like growth factor I, integrins, protein binding, protein isoforms, protein-serine-threonine kinases, receptor, IGF type 1, signal transduction, vitronectin, Pharmacy and materia medica, Cell Biology, Physiology, Clinical Biochemistry
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Pure Administrator
Date Deposited: 26 Oct 2011 09:26
Last modified: 05 Sep 2014 12:49
URI: http://strathprints.strath.ac.uk/id/eprint/35158

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