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Characterisation of an extract from the leaves of Cissampelos sympodials Eichl. on the spontaneous tone of isolated trachea

Thomas, G and Burns, F and Pyne, Susan and Pyne, Nigel (1997) Characterisation of an extract from the leaves of Cissampelos sympodials Eichl. on the spontaneous tone of isolated trachea. Phytotherapy Research, 11. pp. 496-499. ISSN 0951-418X

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Abstract

An aqueous fraction of the ethanol extract of the leaves (AFL) of Cissampelos sympodialis Eichl. (Menispermaceae) was shown to relax the spontaneous tone of guinea-pig tracheal smooth muscle rings with an IC50 of 20.5 μg/mL. The AFL inhibited cyclic nucleotide phosphodiesterase activity in isolated smooth muscle homogenates and stimulated an increase in intracellular cAMP synthesis in intact cultured smooth muscle cells. A complete inhibition of phosphodiesterase activity in isolated homogenates was almost achieved. These studies indicate that the AFL contains a substance which is a non-selective, but highly potent inhibitor of phosphodiesterase activity. This probably accounts for its effect on the spontaneous tone of guinea-pig tracheal smooth muscle.