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Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase

Houslay, M.D. and Bushfield, M and Kilgour, E and Lavan, B E and Griffiths, S and Pyne, Nigel and Tang, I and Murphy, G (1990) Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase. In: Activation and Desensitisation of Transducing Pathways. NATO ASI series, 44 . Springer-Verlag, pp. 63-83. ISBN 9783642836183

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Abstract

Book chapter explains how glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase.