Tate, R J and Lochhead, A and Brzeski, H and Arshavsky, V and Pyne, N J (1998) The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung. Cell Biochemistry and Biophysics, 29 (1-2). pp. 133-144. ISSN 1085-9195
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
The type 6 phosphodiesterase (PDE-6) from retinal rod photoreceptors is an alpha beta gamma 2 heterotetramer. The alpha- and beta-subunits contain catalytic sites for cGMP hydrolysis, whereas the gamma-subunits (P gamma) serve as a protein inhibitor of the enzyme. P gamma is believed to be expressed only in photoreceptors. Using RT-PCR, we have amplified the complete coding sequence for P gamma from mouse lung RNA. The expression of P gamma in this tissue may be related to its ability to interact the type 5 phosphodiesterase (PDE-5), which is the predominant cGMP binding protein in lung. We therefore suggest that P gamma may have a wider signaling role in mammalian cells than previously appreciated.
| Item type: | Article |
|---|---|
| ID code: | 34946 |
| Keywords: | 3',5'-cyclic-GMP phosphodiesterases, amino acid sequence, animals, base sequence, cyclic AMP-dependent protein kinases, cyclic nucleotide phosphodiesterases, type 5, cyclic nucleotide phosphodiesterases, Type 6, enzyme activation, lung, mice, molecular sequence data, RNA, messenger, rod cell outer segment, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 15 Nov 2011 16:01 |
| Last modified: | 04 Oct 2012 14:01 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/34946 |
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