The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung
Tate, R J and Lochhead, A and Brzeski, H and Arshavsky, V and Pyne, N J (1998) The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung. Cell Biochemistry and Biophysics, 29 (1-2). pp. 133-144. ISSN 1085-9195 (https://doi.org/10.1007/BF02737832)
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The type 6 phosphodiesterase (PDE-6) from retinal rod photoreceptors is an alpha beta gamma 2 heterotetramer. The alpha- and beta-subunits contain catalytic sites for cGMP hydrolysis, whereas the gamma-subunits (P gamma) serve as a protein inhibitor of the enzyme. P gamma is believed to be expressed only in photoreceptors. Using RT-PCR, we have amplified the complete coding sequence for P gamma from mouse lung RNA. The expression of P gamma in this tissue may be related to its ability to interact the type 5 phosphodiesterase (PDE-5), which is the predominant cGMP binding protein in lung. We therefore suggest that P gamma may have a wider signaling role in mammalian cells than previously appreciated.
ORCID iDs
Tate, R J, Lochhead, A, Brzeski, H, Arshavsky, V and Pyne, N J ORCID: https://orcid.org/0000-0002-5657-4578;-
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Item type: Article ID code: 34946 Dates: DateEvent1998PublishedKeywords: 3',5'-cyclic-GMP phosphodiesterases, amino acid sequence, animals, base sequence, cyclic AMP-dependent protein kinases, cyclic nucleotide phosphodiesterases, type 5, cyclic nucleotide phosphodiesterases, Type 6, enzyme activation, lung, mice, molecular sequence data, RNA, messenger, rod cell outer segment, Pharmacy and materia medica, Biochemistry, Cell Biology, Biophysics Subjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 15 Nov 2011 16:01 Last modified: 06 Jan 2024 06:46 URI: https://strathprints.strath.ac.uk/id/eprint/34946