Tolan, D and Conway, A M and Steele, L and Pyne, S and Pyne, N J (1996) The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. British Journal of Pharmacology, 119 (2). pp. 185-186. ISSN 0007-1188
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
We present entirely novel evidence that DL-threo dihydrosphingosine and sphingosine are inhibitors of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. We show that DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. We conclude that DL-threo dihydrosphingosine may represent an important pharmacological cell-permeable agent that may be usefully employed to block smooth muscle cell proliferation.
| Item type: | Article |
|---|---|
| ID code: | 34932 |
| Keywords: | animals, bradykinin, calcium-calmodulin-dependent protein kinases, cells, cultured, enzyme activation, enzyme inhibitors, guinea pigs, mitogen-activated protein kinase 1, mitogen-activated protein kinase 3, mitogen-activated protein kinases, muscle, smooth, platelet-derived growth factor, signal transduction, sphingosine, stimulation, chemical, trachea, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 15 Nov 2011 14:47 |
| Last modified: | 12 Mar 2012 11:37 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/34932 |
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