Tolan, D and Conway, A M and Steele, L and Pyne, S and Pyne, N J (1996) The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. British Journal of Pharmacology, 119 (2). pp. 185-186. ISSN 0007-1188Full text not available in this repository. (Request a copy from the Strathclyde author)
We present entirely novel evidence that DL-threo dihydrosphingosine and sphingosine are inhibitors of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. We show that DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. We conclude that DL-threo dihydrosphingosine may represent an important pharmacological cell-permeable agent that may be usefully employed to block smooth muscle cell proliferation.
|Keywords:||animals, bradykinin, calcium-calmodulin-dependent protein kinases, cells, cultured, enzyme activation, enzyme inhibitors, guinea pigs, mitogen-activated protein kinase 1, mitogen-activated protein kinase 3, mitogen-activated protein kinases, muscle, smooth, platelet-derived growth factor, signal transduction, sphingosine, stimulation, chemical, trachea, Pharmacy and materia medica, Pharmacology|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||15 Nov 2011 14:47|
|Last modified:||04 May 2016 20:22|