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The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle

Tolan, D and Conway, A M and Steele, L and Pyne, S and Pyne, N J (1996) The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. British Journal of Pharmacology, 119 (2). pp. 185-186. ISSN 0007-1188

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Abstract

We present entirely novel evidence that DL-threo dihydrosphingosine and sphingosine are inhibitors of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. We show that DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. We conclude that DL-threo dihydrosphingosine may represent an important pharmacological cell-permeable agent that may be usefully employed to block smooth muscle cell proliferation.

Item type: Article
ID code: 34932
Keywords: animals, bradykinin, calcium-calmodulin-dependent protein kinases, cells, cultured, enzyme activation, enzyme inhibitors, guinea pigs, mitogen-activated protein kinase 1, mitogen-activated protein kinase 3, mitogen-activated protein kinases, muscle, smooth, platelet-derived growth factor, signal transduction, sphingosine, stimulation, chemical, trachea, Pharmacy and materia medica, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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    Depositing user: Pure Administrator
    Date Deposited: 15 Nov 2011 14:47
    Last modified: 05 Sep 2014 12:34
    URI: http://strathprints.strath.ac.uk/id/eprint/34932

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