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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?

Houslay, M D and Wallace, A V and Cooper, M E and Pyne, Nigel and Wilson, S R and Heyworth, C M (1984) Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein? Biochemical Society Transactions, 12 (5). pp. 766-8. ISSN 0300-5127

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Abstract

One of the central features of insulin’s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .