Houslay, M D and Wallace, A V and Cooper, M E and Pyne, Nigel and Wilson, S R and Heyworth, C M (1984) Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein? Biochemical Society Transactions, 12 (5). pp. 766-8. ISSN 0300-5127Full text not available in this repository. (Request a copy from the Strathclyde author)
One of the central features of insulin’s action on the liver is its ability to antagonize the actions of glucagon. Glucagon switches on glycogenolysis and gluconeogenesis in the liver by raising intracellular cyclic A M P concentrations through stimulating the activity of adenylate cyclase. Insulin would appear to achieve its antagonistic effect by causing a decrease in the intracellular concentrations of cyclic A M P .
|Keywords:||3',5'-cyclic-AMP phosphodiesterases, adenosine diphosphate ribose, adenosine triphosphate, adenylate cyclase, animals, cyclic AMP, enzyme activation, GTP-binding proteins, glucagon, guanosine triphosphate, Insulin, Therapeutics. Pharmacology, Biochemistry|
|Subjects:||Medicine > Therapeutics. Pharmacology|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||14 Nov 2011 10:16|
|Last modified:||06 Jan 2017 10:14|