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Sphingolipids as differential regulators of cellular signalling processes

Pyne, S and Tolan, D G and Conway, A M and Pyne, N (1997) Sphingolipids as differential regulators of cellular signalling processes. Biochemical Society Transactions, 25 (2). pp. 549-556. ISSN 0300-5127

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Abstract

Sphingomyelin is a phospholipid that is preferentially located in the outer leaflet of the plasma membrane of mammalian cells. It can be hydrolysed by three distinct isoforms of a phospholipase C (PLC)-like enzyme, sphingomyelinase, which are distinguished by their pH optima and Mg2+-dependence. Activation of sphingomyelinase occurs in response to stimulation of a number of distinct cell-surface receptors by a variety of biological agonists, such as cytokines and growth factors [l]. Several metabolites of sphingomyelin have been identified as potential second-messenger molecules.

Item type: Article
ID code: 34899
Keywords: protein-kinase, phospholipase-D activation, phosphatidic-acid levels, dependent activation, signaling pathways, kappa-b, sphingosine, Engineering design, Therapeutics. Pharmacology, Biochemistry
Subjects: Technology > Engineering (General). Civil engineering (General) > Engineering design
Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Pure Administrator
Date Deposited: 12 Nov 2011 09:25
Last modified: 01 Oct 2014 16:45
URI: http://strathprints.strath.ac.uk/id/eprint/34899

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