Pyne, S and Tolan, D G and Conway, A M and Pyne, N (1997) Sphingolipids as differential regulators of cellular signalling processes. Biochemical Society Transactions, 25 (2). pp. 549-556. ISSN 0300-5127
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Sphingomyelin is a phospholipid that is preferentially located in the outer leaflet of the plasma membrane of mammalian cells. It can be hydrolysed by three distinct isoforms of a phospholipase C (PLC)-like enzyme, sphingomyelinase, which are distinguished by their pH optima and Mg2+-dependence. Activation of sphingomyelinase occurs in response to stimulation of a number of distinct cell-surface receptors by a variety of biological agonists, such as cytokines and growth factors [l]. Several metabolites of sphingomyelin have been identified as potential second-messenger molecules.
| Item type: | Article |
|---|---|
| ID code: | 34899 |
| Keywords: | protein-kinase, phospholipase-D activation, phosphatidic-acid levels, dependent activation, signaling pathways, kappa-b, sphingosine, Engineering design, Therapeutics. Pharmacology |
| Subjects: | Technology > Engineering (General). Civil engineering (General) > Engineering design Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 12 Nov 2011 09:25 |
| Last modified: | 13 Sep 2012 14:55 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/34899 |
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