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Open Access research that challenges the mind...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including those from the School of Psychological Sciences & Health - but also papers by researchers based within the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

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Sphingolipids as differential regulators of cellular signalling processes

Pyne, S and Tolan, D G and Conway, A M and Pyne, N (1997) Sphingolipids as differential regulators of cellular signalling processes. Biochemical Society Transactions, 25 (2). pp. 549-556. ISSN 0300-5127

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Abstract

Sphingomyelin is a phospholipid that is preferentially located in the outer leaflet of the plasma membrane of mammalian cells. It can be hydrolysed by three distinct isoforms of a phospholipase C (PLC)-like enzyme, sphingomyelinase, which are distinguished by their pH optima and Mg2+-dependence. Activation of sphingomyelinase occurs in response to stimulation of a number of distinct cell-surface receptors by a variety of biological agonists, such as cytokines and growth factors [l]. Several metabolites of sphingomyelin have been identified as potential second-messenger molecules.