Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Catalytic antibodies: a new window on protein chemistry

Suckling, Colin J. and Tedford, Catriona M. and Proctor, George R. and Khalaf, Abedawn I. and Bence, Laura M. and Stimson, William H. (1991) Catalytic antibodies: a new window on protein chemistry. Ciba Foundation Symposium, 159 (Catal.). pp. 201-210. ISSN 0300-5208

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

A review with 10 refs. Catalytic antibodies have created a new dimension in protein chem. In these studies it is particularly valuable to investigate systems for which natural enzymic catalysts are unknown. Several ways of prepg. homochiral building blocks for org. synthesis have been examd. by the authors. Antibodies that catalyze the Diels-Alder reaction have been characterized. The target reaction was the addn. of acetoxybutadiene to N-substituted maleimides, a reaction that should give a pentafunctional homochiral building block. Catalytic antibodies can give insight into the mechanism of catalysis by proteins. An adventitious hydrolytic antibody that cleaves activated esters was investigated. An antibody raised to ampicillin for anal. purposes has also been shown to catalyze hydrolysis of the β-lactam ring.

Item type: Article
ID code: 34889
Notes: M1 - Copyright (C) 2011 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 1993:54708(Journal; General Review)
Keywords: protein chemistry , catalytic antibodies, n-substituted maleimides, Chemistry, General
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 21 Oct 2011 14:44
    Last modified: 05 Sep 2014 12:29
    URI: http://strathprints.strath.ac.uk/id/eprint/34889

    Actions (login required)

    View Item