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Catalytic antibodies: a new window on protein chemistry

Suckling, Colin J. and Tedford, Catriona M. and Proctor, George R. and Khalaf, Abedawn I. and Bence, Laura M. and Stimson, William H. (1991) Catalytic antibodies: a new window on protein chemistry. Ciba Foundation Symposium, 159 (Catal.). pp. 201-210. ISSN 0300-5208

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Abstract

A review with 10 refs. Catalytic antibodies have created a new dimension in protein chem. In these studies it is particularly valuable to investigate systems for which natural enzymic catalysts are unknown. Several ways of prepg. homochiral building blocks for org. synthesis have been examd. by the authors. Antibodies that catalyze the Diels-Alder reaction have been characterized. The target reaction was the addn. of acetoxybutadiene to N-substituted maleimides, a reaction that should give a pentafunctional homochiral building block. Catalytic antibodies can give insight into the mechanism of catalysis by proteins. An adventitious hydrolytic antibody that cleaves activated esters was investigated. An antibody raised to ampicillin for anal. purposes has also been shown to catalyze hydrolysis of the β-lactam ring.