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The influence of cytokines on the glycosylation pattern of alpha-l-acid glycoprotein secreted by the HepC2 cell line

ELLIOTT, H G and ELLIOTT, M A and WATSON, J and SMITH, K D (1995) The influence of cytokines on the glycosylation pattern of alpha-l-acid glycoprotein secreted by the HepC2 cell line. Biochemical Society Transactions, 23 (2). S164-S164. ISSN 0300-5127

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Abstract

Alpha-I-acid glycoprotein (ACP) is a positive acute phase protein which exists as an heterogeneous populationn of glycosylated variants (glycoforms). A clearly defined function for ACP remains largely unknown however several studies have demonstrated immunomodulatory properties. The ACP glycoforms associated with chronic inflammation have an increased number o f tri- or tetra- antennary structures to the detriment o f bi-antennary chains, and are more effective at immunomodulation.