ELLIOTT, H G and ELLIOTT, M A and WATSON, J and SMITH, K D (1995) The influence of cytokines on the glycosylation pattern of alpha-l-acid glycoprotein secreted by the HepC2 cell line. Biochemical Society Transactions, 23 (2). S164-S164. ISSN 0300-5127
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1042/bst023164s
Abstract
Alpha-I-acid glycoprotein (ACP) is a positive acute phase protein which exists as an heterogeneous populationn of glycosylated variants (glycoforms). A clearly defined function for ACP remains largely unknown however several studies have demonstrated immunomodulatory properties. The ACP glycoforms associated with chronic inflammation have an increased number o f tri- or tetra- antennary structures to the detriment o f bi-antennary chains, and are more effective at immunomodulation.
| Item type: | Article |
|---|---|
| ID code: | 34866 |
| Keywords: | proteins, cytokines , glycosylation , immunomodulation, Therapeutics. Pharmacology |
| Subjects: | Medicine > Therapeutics. Pharmacology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 11 Nov 2011 14:23 |
| Last modified: | 12 Mar 2012 11:37 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/34866 |
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