ELLIOTT, H G and ELLIOTT, M A and WATSON, J and SMITH, K D (1995) The influence of cytokines on the glycosylation pattern of alpha-l-acid glycoprotein secreted by the HepC2 cell line. Biochemical Society Transactions, 23 (2). S164-S164. ISSN 0300-5127Full text not available in this repository. (Request a copy from the Strathclyde author)
Alpha-I-acid glycoprotein (ACP) is a positive acute phase protein which exists as an heterogeneous populationn of glycosylated variants (glycoforms). A clearly defined function for ACP remains largely unknown however several studies have demonstrated immunomodulatory properties. The ACP glycoforms associated with chronic inflammation have an increased number o f tri- or tetra- antennary structures to the detriment o f bi-antennary chains, and are more effective at immunomodulation.
|Keywords:||proteins, cytokines , glycosylation , immunomodulation, Therapeutics. Pharmacology, Biochemistry|
|Subjects:||Medicine > Therapeutics. Pharmacology|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||11 Nov 2011 14:23|
|Last modified:||09 Feb 2017 01:04|