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World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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The influence of cytokines on the glycosylation pattern of alpha-l-acid glycoprotein secreted by the HepC2 cell line

ELLIOTT, H G and ELLIOTT, M A and WATSON, J and SMITH, K D (1995) The influence of cytokines on the glycosylation pattern of alpha-l-acid glycoprotein secreted by the HepC2 cell line. Biochemical Society Transactions, 23 (2). S164-S164. ISSN 0300-5127

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Abstract

Alpha-I-acid glycoprotein (ACP) is a positive acute phase protein which exists as an heterogeneous populationn of glycosylated variants (glycoforms). A clearly defined function for ACP remains largely unknown however several studies have demonstrated immunomodulatory properties. The ACP glycoforms associated with chronic inflammation have an increased number o f tri- or tetra- antennary structures to the detriment o f bi-antennary chains, and are more effective at immunomodulation.