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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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The influence of cytokines on the glycosylation pattern of alpha-l-acid glycoprotein secreted by the HepC2 cell line

ELLIOTT, H G and ELLIOTT, M A and WATSON, J and SMITH, K D (1995) The influence of cytokines on the glycosylation pattern of alpha-l-acid glycoprotein secreted by the HepC2 cell line. Biochemical Society Transactions, 23 (2). S164-S164. ISSN 0300-5127

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Abstract

Alpha-I-acid glycoprotein (ACP) is a positive acute phase protein which exists as an heterogeneous populationn of glycosylated variants (glycoforms). A clearly defined function for ACP remains largely unknown however several studies have demonstrated immunomodulatory properties. The ACP glycoforms associated with chronic inflammation have an increased number o f tri- or tetra- antennary structures to the detriment o f bi-antennary chains, and are more effective at immunomodulation.