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Potassium channels underlying the resting potential of pulmonary artery smooth muscle cells

Gurney, Alison and Osipenko, Oleg and MacMillan, Debbi and Kempsill, Fiona (2002) Potassium channels underlying the resting potential of pulmonary artery smooth muscle cells. Clinical and Experimental Pharmacology and Physiology, 29 (4). pp. 330-333.

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Abstract

1. The molecular identity of the K channels giving rise to the negative membrane potential of pulmonary artery smooth muscle cells has yet to be determined. 2. To date, most studies have focused on voltage-gated, delayed rectifier channels and their roles in mediating hypoxia-induced membrane depolarization. There is, however, strong evidence that an outwardly rectifying K+ conductance distinct from the classical delayed rectifier is involved. 3. Growing evidence that TASK-like channels can sense hypoxia and are present in pulmonary artery smooth muscle cells suggests that they may be responsible for the resting K+ conductance and resting potential. 4. The present review considers the evidence that particular K channels maintain the resting membrane potential of pulmonary artery smooth muscle cells and mediate the depolarizing response to hypoxia.