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Sphingosine kinase inhibitors and cancer : seeking the golden sword of Hercules

Pyne, Susan and Bittman, Robert and Pyne, Nigel (2011) Sphingosine kinase inhibitors and cancer : seeking the golden sword of Hercules. Cancer Research, 71 (21). pp. 6576-6582. ISSN 0008-5472

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Abstract

There is considerable evidence that sphingosine kinases play a key role in cancer progression, which might involve positive selection of cancer cells that have been provided with a survival and growth advantage as a consequence of overexpression of the enzyme. Therefore, inhibitors of sphingosine kinase represent a novel class of compounds that have potential as anticancer agents. Poor inhibitor potency is a major issue that has precluded successful translation of these compounds into the clinic. However, recent discoveries have shown that sphingosine kinase 1 is an allosteric enzyme and that some inhibitors offer improved effectiveness by inducing proteasomal degradation of the enzyme or having nanomolar potency. Herein, we provide a perspective about these recent developments and highlight the importance of translating basic pharmacologic and biochemical findings on sphingosine kinase into new drug discovery programs for treatment of cancer.

Item type: Article
ID code: 34630
Keywords: sphingosine kinase inhibitors, cancer, hercules, golden sword, Pharmacy and materia medica, Cancer Research, Oncology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Pure Administrator
Date Deposited: 17 Oct 2011 14:29
Last modified: 26 Sep 2014 17:04
URI: http://strathprints.strath.ac.uk/id/eprint/34630

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