Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

Synthesis, characterisation and a theoretical investigation of the formation of lithium dialkylaluminium amides

Clegg, W and Liddle, S T and Henderson, K W and Keenan, F E and Kennedy, A R and McKeown, A E and Mulvey, R E (1999) Synthesis, characterisation and a theoretical investigation of the formation of lithium dialkylaluminium amides. Journal of Organometallic Chemistry, 572 (2). pp. 283-289. ISSN 0022-328X

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Reaction of the pre-formed crystalline amides [(PhCH2)(2)NLi] and [Me2AlN(CH2Ph)(2)] in the presence of pyridine results in the formation of the mixed metal complex [Me2Al{(PhCH2)(2)N}(2)Li . pyr] 1. Ab initio molecular orbital calculations indicate formation of the bimetallic product is energetically favourable. Using single crystal X-ray analysis for 1 and the pyridine solvate [{(PhCH2)(2)NLi . pyr}(2)] 7, in combination with theoretical calculations, the possible driving forces for the reaction are discussed. A major contributing factor in the stabilisation of the bimetallic compound was found to be a reduction in steric crowding in the mixed metal base compared to the homometallic dialkylaluminium amide. In addition, complex 1 shows significant benzyl to lithium interactions which contribute to the overall bonding. Such interactions are unusual in that donor solvent is present as competing complexant.