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Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells

Nicholls, David and Vesce, Sabino and Kirk, Liana and Chalmers, Susan (2003) Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells. Cell Calcium, 34 (4-5). pp. 407-424. ISSN 0143-4160

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Abstract

The mitochondrion has moved to the center stage in the drama of the life and death of the neuron. The mitochondrial membrane potential controls the ability of the organelle to generate ATP, generate reactive oxygen species and sequester Ca(2+) entering the cell. Each of these processes interact, and their deconvolution is far from trivial. The cultured cerebellar granule cell provides a model in which knowledge gained from studies on isolated mitochondria can be applied to study the role played by the organelles in the maintenance of Ca(2+) homeostasis in the cell under resting, stimulated and pathophysiological conditions. In particular, mitochondria play a complex role in the response of the neuron to excitotoxic stimulation of NMDA and AMPA-kainate selective glutamate receptors. One goal of research in this area is to provide clues as to possible ways in which modulators of mitochondrial function may be used as neuroprotective agents, since mitochondrial Ca(2+) accumulation seems to play a key role in glutamate excitotoxicity.

Item type: Article
ID code: 34426
Keywords: bioenergetics, glutamate, membrane potential, mitochondria, cerebellar granule cells, cytoplasmic calcium, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 11 Oct 2011 16:18
    Last modified: 12 Mar 2012 11:36
    URI: http://strathprints.strath.ac.uk/id/eprint/34426

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