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The bioinorganic chemistry of methimazole based soft scorpionates

Reglinski, John and Spicer, Mark D. (2009) The bioinorganic chemistry of methimazole based soft scorpionates. Current Bioactive Compounds, 5 (4). pp. 264-276.

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Abstract

Interest in the biomimetic properties of soft scorpionates based on methimazole commenced shortly after the reported synthesis of the hydrotris(methimazolyl)borate anion (TmMe) in 1996. These ligands are thione based and are thus not subject to facile oxidation and disulfide formation (c.f. thiolates). This allows these species to participate in an extensive coordination chemistry with a wide variety of metals. This review focuses on the chemistry of the RTmR and RBmR ligands with special reference to their use in biomimetic chemistry (alcohol dehydrogenase, Ada repair proteins, 5- aminolevulinate dehydratase, sulfite oxidase, hydrogenase, MerB) and their emerging use as radiopharmaceuticals (rhenium, technetium).

Item type: Article
ID code: 34297
Keywords: soft scorpionates, methimazole, biomimetic properties, ligands, Chemistry, Pharmacology, Toxicology and Pharmaceutics(all)
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 06 Oct 2011 19:11
    Last modified: 05 Sep 2014 11:48
    URI: http://strathprints.strath.ac.uk/id/eprint/34297

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