Bagley, Mark C. and Hughes, David D. and Lubinu, M. Caterina and Merritt, Eleanor A. and Taylor, Paul H. and Tomkinson, Nicholas C. O. (2004) Microwave-assisted synthesis of pyrimidine libraries. QSAR and Combinatorial Science, 23 (10). pp. 859-867. ISSN 1611-020X
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Di- and trisubstituted pyrimidine libraries are prepd. in good yields by the microwave irradn. of an alkynone R1C≡CCOR2 [R1 = H, Ph; R2 = Ph, 4-MeOC6H4, 3,4-(MeO)2C6H3, etc.] and either an amidine or guanidine at 120-150° in acetonitrile in the presence of sodium carbonate or at 100° after treatment with methanolic sodium methoxide in a sealed tube using a monomodal microwave synthesizer. These rapid and efficient methods often require no chromatog. purifn. and so are appropriate for automated combinatorial methodol. and have been applied in the synthesis of a small library of potentially useful novel ligands for the estrogen receptor based on the pyrimidine template.
| Item type: | Article |
|---|---|
| ID code: | 34249 |
| Notes: | M1 - Copyright (C) 2011 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2005:40257(Journal) |
| Keywords: | pyrimidine libraries , microwave-assisted synthesis, novel ligands , Chemistry |
| Subjects: | Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 20 Oct 2011 15:15 |
| Last modified: | 04 Oct 2012 13:56 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/34249 |
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