Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands.

Tomkinson, Nicholas C. O. and Sefler, Andrea M. and Plunket, Kelli D. and Blanchard, Steven G. and Parks, Derek J. and Willson, Timothy M. (1997) Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands. Bioorganic and Medicinal Chemistry Letters, 7 (19). pp. 2491-2496. ISSN 0960-894X (https://doi.org/10.1016/S0960-894X(97)10017-8)

Abstract

A library of thiazolidinedione-fatty acid hybrid mols. was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARγ ligands.

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• Item metadata

  Item type:	Article
  ID code:	34222
  Dates:	Date Event 1997 Published
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	20 Oct 2011 15:31
  Last modified:	08 Apr 2024 19:29
  URI:	https://strathprints.strath.ac.uk/id/eprint/34222