Efficient, stereoselective synthesis of 24(S),25-epoxycholesterol
Tomkinson, Nicholas C. O. and Willson, Timothy M. and Spencer, Thomas A. and Russell, Jonathon S. (1998) Efficient, stereoselective synthesis of 24(S),25-epoxycholesterol. In: 216th National Meeting of the American Chemical Society, 1998-08-23 - 1998-08-27.
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Efficient, stereoselective syntheses of 24(S),25-epoxycholesterol (1) have been developed starting from cholenic acid (2) or stigmasterol (3), both featuring as the key step Sharpless asym. dihydroxylation of desmosterol acetate (4). This work permits prepn. of gram quantities of 1 for further evaluation as a natural regulator of cholesterol metab., specifically, e.g., as a ligand for the LXRα nuclear receptor. [on SciFinder(R)]
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Item type: Conference or Workshop Item(Other) ID code: 34221 Dates: DateEvent1998PublishedNotes: CAPLUS AN 1998:530388(Conference; Meeting Abstract) Subjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 15 Nov 2011 15:56 Last modified: 27 Jan 2024 21:50 URI: https://strathprints.strath.ac.uk/id/eprint/34221
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