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Differential activity of rosiglitazone enantiomers at PPARγ

Parks, Derek J. and Tomkinson, Nicholas C. O. and Villeneuve, Manon S. and Blanchard, Steven G. and Willson, Timothy M. (1998) Differential activity of rosiglitazone enantiomers at PPARγ. Bioorganic and Medicinal Chemistry Letters, 8 (24). pp. 3657-3658. ISSN 0960-894X

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Abstract

Anal. of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the (S)-(-)- isomer is responsible for the antidiabetic activity.

Item type: Article
ID code: 34216
Notes: M1 - Copyright (C) 2011 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 1999:50739(Journal)
Keywords: rosiglitazone enantiomers , rosiglitazone , antidiabetic activity, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Clinical Biochemistry
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 20 Oct 2011 16:22
    Last modified: 05 Sep 2014 11:41
    URI: http://strathprints.strath.ac.uk/id/eprint/34216

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