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Differential activity of rosiglitazone enantiomers at PPARγ

Parks, Derek J. and Tomkinson, Nicholas C. O. and Villeneuve, Manon S. and Blanchard, Steven G. and Willson, Timothy M. (1998) Differential activity of rosiglitazone enantiomers at PPARγ. Bioorganic and Medicinal Chemistry Letters, 8 (24). pp. 3657-3658. ISSN 0960-894X

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Abstract

Anal. of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the (S)-(-)- isomer is responsible for the antidiabetic activity.