Spencer Thomas A., Jr. and Li, Dansu and Russel, Jonathon S. and Tomkinson, Nicholas C. O. and Willson, Timothy M. (2000) Further studies on synthesis of 24(S),25-epoxycholesterol : new efficient preparation of desmosterol. In: 219th Meeting of the American Chemical Society, 2000-03-26 - 2000-03-30, San Francisco.
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Our synthesis of the regulatory oxysterol 24(S),25-epoxycholesterol (1) from stigmasterol has been improved by the discovery that cuprate 2 can be coupled with allylic acetate 3 to give in 73% yield in the key step of the most effecient conversion yet of a C22 intermediate to desmosteryl acetate (4). Efforts to prep. diol 5 from sulfone 6 via Payne rearrangement of epoxide 7 will also be presented. [on SciFinder(R)]
| Item type: | Conference or Workshop Item (Other) |
|---|---|
| ID code: | 34210 |
| Notes: | CAPLUS AN 2000:332149(Conference; Meeting Abstract) |
| Keywords: | synthesis, 24(s), 25-epoxycholesterol, efficient perparation, desmosterol, Chemistry |
| Subjects: | Science > Chemistry |
| Department: | Faculty of Science > Pure and Applied Chemistry |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 16 Nov 2011 16:33 |
| Last modified: | 04 Oct 2012 17:50 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/34210 |
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