Picture of virus under microscope

Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

Explore SIPBS research

A general method for the α-acyloxylation of carbonyl compounds

Beshara, Cory S. and Hall, Adrian and Jenkins, Robert L. and Jones, Kerri L. and Jones, Teyrnon C. and Killeen, Niall M. and Taylor, Paul H. and Thomas, Stephen P. and Tomkinson, Nicholas C. O. (2005) A general method for the α-acyloxylation of carbonyl compounds. Organic Letters, 7 (25). pp. 5729-5732. ISSN 1523-7060

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

A simple, one-pot method for the α-acyloxylation of carbonyl compds. that proceeded at room temp. in the presence of both moisture and air has been developed. Treatment of a variety of aldehydes and both cyclic and acyclic ketones with N-methyl-O-benzoylhydroxylamine hydrochloride provided the α-functionalized product in good isolated yield. The transformation was tolerant of a wide range of functional groups and, significantly, was regiospecific in the discrimination of secondary over primary centers in the case of nonsym. substrates.