Cavill, Julie L. and Elliott, Richard L. and Evans, Gareth and Jones, Ian L. and Platts, James A. and Ruda, Antonio M. and Tomkinson, Nicholas C. O. (2005) The α-effect in iminium ion catalysis. Tetrahedron, 62 (2-3). pp. 410-421. ISSN 0040-4020Full text not available in this repository. (Request a copy from the Strathclyde author)
The α-effect can be used as an effective means to promote iminium ion catalyzed transformations, providing acyclic scaffolds to aid in catalyst design. A thorough investigation of the structure-activity relationship of the catalyst architecture reveals optimal substituents of a disubstituted carbamate and a secondary alkyl group around a hydrazine scaffold. Mol. modeling investigations provide a mechanistic rationale to the results obsd.
|Keywords:||ion catalysis, iminium ion catalysis , hydrazine scaffold, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery|
|Subjects:||Science > Chemistry|
|Department:||Faculty of Science > Pure and Applied Chemistry|
|Depositing user:||Pure Administrator|
|Date Deposited:||20 Oct 2011 14:05|
|Last modified:||27 Apr 2016 17:28|