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Methods for nanoparticle labeling of ricin and effect on toxicity

Wark, Alastair and Yu, Jun and Lindsay, C. D. and Nativo, Paola and Graham, Duncan (2009) Methods for nanoparticle labeling of ricin and effect on toxicity. In: Methods for nanoparticle labeling of ricin and effect on toxicity. SPIE--The International Society for Optical Engineering..

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Abstract

The unique optical properties associated with nanostructured materials that support the excitation of surface plasmons offer many new opportunities for the enhanced optical investigation of biological materials that pose a security threat. In particular, ricin is considered a significant bioterrorism risk due to its high toxicity combined with its ready availability as a byproduct in castor oil production. Therefore, the development of optical techniques capable of rapid on-site toxin detection with high molecular specificity and sensitivity continues to be of significant importance. Furthermore, understanding of the ricin cell entry and intracellular pathways remains poor due to a lack of suitable bioanalytical techniques. Initial work aimed at simultaneously tackling both these issues is described where different approaches for the nanoparticle labeling of ricin are investigated along with changes in ricin toxicity associated with the labeling process.

Item type: Book Section
ID code: 34126
Subjects: UNSPECIFIED
Department: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date Deposited: 24 Oct 2011 12:33
Last modified: 21 May 2015 19:29
URI: http://strathprints.strath.ac.uk/id/eprint/34126

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