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Methods for nanoparticle labeling of ricin and effect on toxicity

Wark, Alastair and Yu, Jun and Lindsay, C. D. and Nativo, Paola and Graham, Duncan (2009) Methods for nanoparticle labeling of ricin and effect on toxicity. In: Methods for nanoparticle labeling of ricin and effect on toxicity. SPIE--The International Society for Optical Engineering., 748604-1-748604-4.

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    Abstract

    The unique optical properties associated with nanostructured materials that support the excitation of surface plasmons offer many new opportunities for the enhanced optical investigation of biological materials that pose a security threat. In particular, ricin is considered a significant bioterrorism risk due to its high toxicity combined with its ready availability as a byproduct in castor oil production. Therefore, the development of optical techniques capable of rapid on-site toxin detection with high molecular specificity and sensitivity continues to be of significant importance. Furthermore, understanding of the ricin cell entry and intracellular pathways remains poor due to a lack of suitable bioanalytical techniques. Initial work aimed at simultaneously tackling both these issues is described where different approaches for the nanoparticle labeling of ricin are investigated along with changes in ricin toxicity associated with the labeling process.

    Item type: Book Section
    ID code: 34126
    Subjects: UNSPECIFIED
    Department: Faculty of Science > Pure and Applied Chemistry
    Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Related URLs:
      Depositing user: Pure Administrator
      Date Deposited: 24 Oct 2011 13:33
      Last modified: 06 Sep 2014 20:42
      URI: http://strathprints.strath.ac.uk/id/eprint/34126

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