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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

Milner, Jennifer M and Patel, Amit and Davidson, Rose K and Swingler, Tracey E and Desilets, Antoine and Young, David A and Kelso, Elizabeth B and Donell, Simon T and Cawston, Tim E and Clark, Ian M and Ferrell, William R and Plevin, Robin and Lockhart, John C and Leduc, Richard and Rowan, Andrew D (2010) Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis and Rheumatism, 62 (7). pp. 1955-1966.

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Abstract

Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA).