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Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

Milner, Jennifer M and Patel, Amit and Davidson, Rose K and Swingler, Tracey E and Desilets, Antoine and Young, David A and Kelso, Elizabeth B and Donell, Simon T and Cawston, Tim E and Clark, Ian M and Ferrell, William R and Plevin, Robin and Lockhart, John C and Leduc, Richard and Rowan, Andrew D (2010) Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis and Rheumatism, 62 (7). pp. 1955-1966.

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Abstract

Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA).

Item type: Article
ID code: 33825
Keywords: animals, cartilage, articular, cattle, chondrocytes, extracellular matrix, femoral neck fractures, gene expression regulation, enzymologic, humans , matrix metalloproteinases, mice, mice, inbred C57BL, mice, knockout, osteoarthritis, hip, proteinase inhibitory proteins, secretory, receptor, PAR-2, serine endopeptidases, Pharmacy and materia medica, Probabilities. Mathematical statistics, Immunology, Rheumatology, Pharmacology (medical), Immunology and Allergy
Subjects: Medicine > Pharmacy and materia medica
Science > Mathematics > Probabilities. Mathematical statistics
Department: Faculty of Science > Mathematics and Statistics
Faculty of Humanities and Social Sciences (HaSS) > School of Humanities > English
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Pure Administrator
Date Deposited: 15 Mar 2012 15:18
Last modified: 05 Sep 2014 11:16
URI: http://strathprints.strath.ac.uk/id/eprint/33825

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