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Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

Milner, Jennifer M and Patel, Amit and Davidson, Rose K and Swingler, Tracey E and Desilets, Antoine and Young, David A and Kelso, Elizabeth B and Donell, Simon T and Cawston, Tim E and Clark, Ian M and Ferrell, William R and Plevin, Robin and Lockhart, John C and Leduc, Richard and Rowan, Andrew D (2010) Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis and Rheumatism, 62 (7). pp. 1955-1966.

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Abstract

Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA).