Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Correlation between in vitro and in vivo erosion behaviour of erodible tablets using gamma scintigraphy

Ghimire, Manish and Hodges, Lee Ann and Band, Janet and Lindsay, Blythe and O'Mahony, Bridget and McInnes, Fiona J and Mullen, Alexander B and Stevens, Howard N E (2011) Correlation between in vitro and in vivo erosion behaviour of erodible tablets using gamma scintigraphy. European Journal of Pharmaceutics and Biopharmaceutics, 77 (1). pp. 148-157. ISSN 1873-3441

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

In vitro and in vivo erosion behaviour of erodible tablets consisting of glyceryl behenate and low-substituted hydroxypropylcellulose manufactured using three different methods: direct compression (DC), melt granulation (MG) and direct solidification (DS) was investigated. In vitro erosion behaviour was studied using gravimetric and scintigraphic methods. For scintigraphic investigations, the radiolabel was adsorbed onto activated charcoal and incorporated into tablets at a concentration that did not affect the erosion profile. A clinical study was carried out in six healthy volunteers using gamma scintigraphy. Tablet erosion was affected by the preparation method and was found to decrease in the order of preparation method, DC>MG>DS tablets. The mean in vivo onset time for all tablets (DC: 6.7±3.8 min, MG: 18.3±8.1 min, DS: 67±18.9 min) did not differ significantly from in vitro onset time (DC: 5.3±1 min, MG: 16.8±3.9 min, DS: 61.8±4.7 min). The mean in vivo completion times were found to be 36.6±9.7 (DC tablets), 70±18.3 min (MG tablets) and 192.5±39.9 min (DS tablets). Among the three different erodible tablets, MG tablets showed the highest correlation between in vitro and in vivo mean erosion profile and suggested a potential platform to deliver controlled release of water-insoluble compounds.

Item type: Article
ID code: 33815
Notes: Copyright © 2010 Elsevier B.V. All rights reserved.
Keywords: adult, cellulose, cross-over studies, delayed-action preparations, drug compounding, drug delivery systems, excipients, fatty acids, gastrointestinal transit, humans, kinetics, male, middle aged, radionuclide imaging, solubility, tablets, technetium Tc 99m pentetate, young adult, Pharmacy and materia medica, Pharmaceutical Science, Biotechnology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Pharmaceutical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 28 Sep 2011 16:47
    Last modified: 09 Jul 2014 05:03
    URI: http://strathprints.strath.ac.uk/id/eprint/33815

    Actions (login required)

    View Item