Picture of wind turbine against blue sky

Open Access research with a real impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

The Energy Systems Research Unit (ESRU) within Strathclyde's Department of Mechanical and Aerospace Engineering is producing Open Access research that can help society deploy and optimise renewable energy systems, such as wind turbine technology.

Explore wind turbine research in Strathprints

Explore all of Strathclyde's Open Access research content

CHED 309-Functionalized nanoparticles as new tools for bioanalysis

Berger, Jacob and Graham, Duncan (2009) CHED 309-Functionalized nanoparticles as new tools for bioanalysis. Abstracts of papers - American Chemical Society, 238. -. ISSN 0065-7727

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Metallic nanoparticles can be used as basic materials for a wide variety of purposes including building blocks for nanoassemblies, substrates for enhanced spectroscopies such as fluorescence and Raman, and as labels for biomolecules. Here we report how silver and gold nanoparticles can be functionalized with specific biomolecular probes to indicate the molecular recognition of a target molecule. Examples of this approach include DNA hybridization to switch on surface enhanced resonance Raman scattering (SERRS) when a specific target sequence is present, recognition of specific proteins by aptamer functionalised nanoparticles through surface plasmon resonance or SERRS, and the use of nanoparticles functionalized with antibodies to provide a new type of immunoassay. These examples indicate how nanoparticles can be used to provide highly sensitive and informative data from a variety of biological systems when used with optical spectroscopy.