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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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CHED 309-Functionalized nanoparticles as new tools for bioanalysis

Berger, Jacob and Graham, Duncan (2009) CHED 309-Functionalized nanoparticles as new tools for bioanalysis. Abstracts of papers - American Chemical Society, 238. -. ISSN 0065-7727

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Abstract

Metallic nanoparticles can be used as basic materials for a wide variety of purposes including building blocks for nanoassemblies, substrates for enhanced spectroscopies such as fluorescence and Raman, and as labels for biomolecules. Here we report how silver and gold nanoparticles can be functionalized with specific biomolecular probes to indicate the molecular recognition of a target molecule. Examples of this approach include DNA hybridization to switch on surface enhanced resonance Raman scattering (SERRS) when a specific target sequence is present, recognition of specific proteins by aptamer functionalised nanoparticles through surface plasmon resonance or SERRS, and the use of nanoparticles functionalized with antibodies to provide a new type of immunoassay. These examples indicate how nanoparticles can be used to provide highly sensitive and informative data from a variety of biological systems when used with optical spectroscopy.