Picture of a black hole

Strathclyde Open Access research that creates ripples...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of research papers by University of Strathclyde researchers, including by Strathclyde physicists involved in observing gravitational waves and black hole mergers as part of the Laser Interferometer Gravitational-Wave Observatory (LIGO) - but also other internationally significant research from the Department of Physics. Discover why Strathclyde's physics research is making ripples...

Strathprints also exposes world leading research from the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

Discover more...

CHED 309-Functionalized nanoparticles as new tools for bioanalysis

Berger, Jacob and Graham, Duncan (2009) CHED 309-Functionalized nanoparticles as new tools for bioanalysis. Abstracts of papers - American Chemical Society, 238. -. ISSN 0065-7727

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Metallic nanoparticles can be used as basic materials for a wide variety of purposes including building blocks for nanoassemblies, substrates for enhanced spectroscopies such as fluorescence and Raman, and as labels for biomolecules. Here we report how silver and gold nanoparticles can be functionalized with specific biomolecular probes to indicate the molecular recognition of a target molecule. Examples of this approach include DNA hybridization to switch on surface enhanced resonance Raman scattering (SERRS) when a specific target sequence is present, recognition of specific proteins by aptamer functionalised nanoparticles through surface plasmon resonance or SERRS, and the use of nanoparticles functionalized with antibodies to provide a new type of immunoassay. These examples indicate how nanoparticles can be used to provide highly sensitive and informative data from a variety of biological systems when used with optical spectroscopy.