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World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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CHED 146-Functionalized nanoparticles as responsive nanobiosensors

Pascoe, Cherilyn and Graham, Duncan (2008) CHED 146-Functionalized nanoparticles as responsive nanobiosensors. Abstracts of papers - American Chemical Society, 236. -. ISSN 0065-7727

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Abstract

Modern molecular diagnostics relies on a variety of different approaches. One that is increasing in popularity involves functionalised metallic nanoparticles as responsive nanobiosensors. Surface enhanced resonance Raman scatting (SERRS) use metallic nanoparticles of silver or gold to enhance the Raman scatting of the target. In this study, metallic nanoparticles are functionalized with a biomolecular probe (e.g. an antibody) to form a nanobiosensor. SERRS is achieved by attaching a reporter dye to the nanoparticle and biomolecular probe. These sensors can be used to analyze an antigen representative of a particular disease. This study focuses on the investigation of functionalized nanoparticles as responsive SERRS nanobiosensors for ultrasensitive analysis.