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Research under the microscope...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Micro-/nano-patterning of DNA and rapid readout with SERS tags

Sun, Shuqing and Thompson, David and Schmidt, Ute and Graham, Duncan and Leggett, Graham J. (2010) Micro-/nano-patterning of DNA and rapid readout with SERS tags. Chemical Communications (London), 46 (29). pp. 5292-5294. ISSN 0009-241X

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Abstract

Hybridisation of oligonucleotide micro-and nano-structures, formed using far-and near-field optical lithography, with Raman dye-labelled silver nanoparticles functionalised with complementary oligonucleotides yields striking contrast, attributed to Raman "hot-spot'' formation, and enables rapid, convenient read-out by Raman microscopy.