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World class computing and information science research at Strathclyde...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by researchers from the Department of Computer & Information Sciences involved in mathematically structured programming, similarity and metric search, computer security, software systems, combinatronics and digital health.

The Department also includes the iSchool Research Group, which performs leading research into socio-technical phenomena and topics such as information retrieval and information seeking behaviour.

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DNA nanofabrication by scanning near-field photolithography of oligo (ethylene glycol) terminated SAMs: Controlled scan-rate dependent switching between head group oxidation and tail group degradation

Sun, Shuqing and Thompson, David G. and Graham, Duncan and Leggett, Graham J. (2011) DNA nanofabrication by scanning near-field photolithography of oligo (ethylene glycol) terminated SAMs: Controlled scan-rate dependent switching between head group oxidation and tail group degradation. Journal of Materials Chemistry, 21 (37). pp. 14173-14177. ISSN 0959-9428

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Abstract

The use of scanning near-field photolithography (SNP) to fabricate DNA nanostructures is described. Two different strategies were employed to generate nanoscale features in oligo(ethylene glycol) (OEG) terminated alkylthiolate self-assembled monolayers (SAMs) on gold. At long exposure times, complete photooxidation of the SAM molecules enabled their displacement by amino-terminated thiol molecules, which were subsequently used to attach ss-DNA molecules; while short exposure times resulted in partial photochemical conversion of the terminal OEG group of the adsorbate to an aldehyde group facilitating the direct attachment of amino-DNA molecules. Arrays of DNA functionalized metal-nanoparticles were then assembled onto the ss-DNA patches through specific DNA hybridization. This methodology provides a facile approach for the assembly of bio-functionalised nanoparticles onto nanofeatures embedded in an inert background and will prove useful in biosensing applications.