DAEID, N N and ATKINSON, S T and NOLAN, K B (1993) Synthetic Porphyrins/Metalloporphyrins Which Mimic States in Catalytic Cycle of Cytochrome P-450 and Peroxidases. Pure and applied chemistry, 65 (7). pp. 1541-1548. ISSN 0033-4545Full text not available in this repository. (Request a copy from the Strathclyde author)
The reaction of thiolates, RS-, having electron withdrawing groups with iron(III) tetra-arylporphyrins in DMSO,in air gives low-spin Fe(III)-P(-SR)2, having hyperporphyrin spectra similar to thiolate derivatives of cytochrome P-450. Removal of air gives high spin Fe(II)-P(-SR) which on addition of CO results in H+ uptake and formation of Fe(II)-P(SHR)CO. Addition of thiols and base to the iron(III) porphyrins in toluene in the absence of air gives 4-coordinate Fe(II)-P which in the presence of CO gives Fe(II)-P(SHR)CO. Metal complexes of one of the porphyrins studied i.e. a tetraphenolic porphyrin undergo 2e- oxidation in air to give quinonoid species which oxidise peroxidase substrates. Rate constants for some of these reactions are reported.
|Keywords:||facile area oxidation, polyvalent porphyrins, complexes, Physical and theoretical chemistry, Chemical Engineering(all), Chemistry(all)|
|Subjects:||Science > Chemistry > Physical and theoretical chemistry|
|Department:||Faculty of Science > Pure and Applied Chemistry|
|Depositing user:||Pure Administrator|
|Date Deposited:||17 Oct 2011 09:38|
|Last modified:||04 May 2016 19:34|