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Synthesis of benzoxazolones from nitroarenes or aryl halides

Porzelle, Achim and Woodrow, Michael D and Tomkinson, Nicholas (2010) Synthesis of benzoxazolones from nitroarenes or aryl halides. Organic Letters, 12 (4). pp. 812-815. ISSN 1523-7060

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Abstract

A simple and effective method for the preparation of benzoxazolones from nitroarenes or aryl halides is described. Partial reduction of a nitro group in the presence of a chloroformate followed by a microwave assisted rearrangement/ring closure sequence provides a convenient and practical procedure to prepare this important pharmacophore. Rearrangement precursors were also accessed from aryl halides through transition-metal catalyzed coupling.

Item type: Article
ID code: 33074
Keywords: highly efficient nitration, oxidative cyclocarbonylation, betaaminoalcohols, phenolic-compounds, Palladium, hydroxylamines, 2-aminophenol, carbonylation, rearrangement, iodides, Therapeutics. Pharmacology, Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Pure and Applied Chemistry
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 31 Aug 2011 15:08
    Last modified: 05 Sep 2014 10:30
    URI: http://strathprints.strath.ac.uk/id/eprint/33074

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