Porzelle, Achim and Woodrow, Michael D and Tomkinson, Nicholas (2010) Synthesis of benzoxazolones from nitroarenes or aryl halides. Organic Letters, 12 (4). pp. 812-815. ISSN 1523-7060Full text not available in this repository. (Request a copy from the Strathclyde author)
A simple and effective method for the preparation of benzoxazolones from nitroarenes or aryl halides is described. Partial reduction of a nitro group in the presence of a chloroformate followed by a microwave assisted rearrangement/ring closure sequence provides a convenient and practical procedure to prepare this important pharmacophore. Rearrangement precursors were also accessed from aryl halides through transition-metal catalyzed coupling.
|Keywords:||highly efficient nitration, oxidative cyclocarbonylation, betaaminoalcohols, phenolic-compounds, Palladium, hydroxylamines, 2-aminophenol, carbonylation, rearrangement, iodides, Therapeutics. Pharmacology, Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry|
|Subjects:||Medicine > Therapeutics. Pharmacology|
|Department:||Faculty of Science > Pure and Applied Chemistry|
|Depositing user:||Pure Administrator|
|Date Deposited:||31 Aug 2011 14:08|
|Last modified:||04 May 2016 19:24|