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Experimental studies of pedunculopontine functions: are they motor, sensory or integrative?

Winn, Philip (2008) Experimental studies of pedunculopontine functions: are they motor, sensory or integrative? Parkinsonism and Related Disorders, 14 Suppl . S194-8. ISSN 1353-8020

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Abstract

The pedunculopontine tegmental nucleus (PPTg) is involved in Parkinson's disease and has become a therapeutic target. However, its normal functions are uncertain: are they motor, sensory or integrative? This position paper reviews PPTg structure and considers experiments designed to understand its behavioural functions. The PPTg is part of the corticostriatal architecture and, consistent with this, a core deficit following lesion is the inability to properly establish action-outcome associations. Understanding normal PPTg structure and function will provide insight into the role it has in Parkinson's disease and related disorders, and will benefit the development of surgical treatments aimed here.

Item type: Article
ID code: 32776
Keywords: animals, deep brain stimulation, neural pathways, parkinson disease, pedunculopontine tegmental nucleus , Therapeutics. Pharmacology, Clinical Neurology, Geriatrics and Gerontology, Neurology
Subjects: Medicine > Therapeutics. Pharmacology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 24 Aug 2011 12:46
    Last modified: 05 Sep 2014 10:18
    URI: http://strathprints.strath.ac.uk/id/eprint/32776

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