Curto, Carina and Sakata, Shuzo and Marguet, Stephan and Itskov, Vladimir and Harris, Kenneth D (2009) A simple model of cortical dynamics explains variability and state dependence of sensory responses in urethane-anesthetized auditory cortex. Journal of Neuroscience, 29 (34). pp. 10600-10612.Full text not available in this repository. (Request a copy from the Strathclyde author)
The responses of neocortical cells to sensory stimuli are variable and state dependent. It has been hypothesized that intrinsic cortical dynamics play an important role in trial-to-trial variability; the precise nature of this dependence, however, is poorly understood. We show here that in auditory cortex of urethane-anesthetized rats, population responses to click stimuli can be quantitatively predicted on a trial-by-trial basis by a simple dynamical system model estimated from spontaneous activity immediately preceding stimulus presentation. Changes in cortical state correspond consistently to changes in model dynamics, reflecting a nonlinear, self-exciting system in synchronized states and an approximately linear system in desynchronized states. We propose that the complex and state-dependent pattern of trial-to-trial variability can be explained by a simple principle: sensory responses are shaped by the same intrinsic dynamics that govern ongoing spontaneous activity.
|Keywords:||acoustic stimulation, anesthetics, animals, auditory cortex, electric stimulation, evoked potentials, neural pathways, neurons, nonlinear dynamics, pedunculopontine tegmental nucleus, rats, urethane, Therapeutics. Pharmacology, Neuroscience(all)|
|Subjects:||Medicine > Therapeutics. Pharmacology|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Pure Administrator|
|Date Deposited:||23 Aug 2011 15:37|
|Last modified:||27 Apr 2016 17:05|