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Enhanced CML stem cell elimination in vitro by bryostatin priming with imatinib mesylate

Jørgensen, Heather G and Allan, Elaine K and Mountford, Joanne C and Richmond, Linda and Harrison, Simon and Elliott, Moira A and Holyoake, Tessa L (2005) Enhanced CML stem cell elimination in vitro by bryostatin priming with imatinib mesylate. Experimental Hematology, 33 (10). pp. 1140-6. ISSN 0301-472X

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Abstract

In chronic myeloid leukemia (CML), imatinib mesylate (IM; Gleevec, Glivec) induces a G0/G1 cell-cycle block in total CD34(+) cells without causing significant apoptosis. Bryostatin-1 (bryo), a protein kinase C (PKC) modulator, was investigated for its ability to increase IM-mediated apoptosis either through induction of cycling of G0/G1 Ph(+) cells or antagonism of the IM-induced cell-cycle block.

Item type: Article
ID code: 32632
Keywords: antigens, antineoplastic agents, apoptosis, bryostatins, drug antagonism, hematopoietic stem cells, leukemia, macrolides, piperazines, protein kinase C, pyrimidines, Therapeutics. Pharmacology, Neoplasms. Tumors. Oncology (including Cancer), Cell Biology, Genetics, Molecular Biology, Hematology, Cancer Research
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Pure Administrator
    Date Deposited: 19 Aug 2011 21:05
    Last modified: 05 Sep 2014 10:13
    URI: http://strathprints.strath.ac.uk/id/eprint/32632

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