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Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor

Stanway, Susannah J and Purohit, Atul and Woo, L W Lawrence and Sufi, Saulat and Vigushin, David and Ward, Rebecca and Wilson, Richard H and Stanczyk, Frank Z and Dobbs, Nicola and Kulinskaya, Elena and Elliott, Moira and Potter, Barry V L and Reed, Michael J and Coombes, R Charles (2006) Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clinical Cancer Research, 12 (5). pp. 1585-92. ISSN 1078-0432

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Abstract

Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties.

Item type: Article
ID code: 32631
Keywords: androstenediol, breast neoplasms, coumarins, estradiol, estrone, neoplasm metastasis, neoplasms, sulfonamides, testosterone, Therapeutics. Pharmacology, Neoplasms. Tumors. Oncology (including Cancer)
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)
Department: Strathclyde Business School > Accounting and Finance
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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    Depositing user: Pure Administrator
    Date Deposited: 19 Aug 2011 12:00
    Last modified: 17 Jul 2013 10:45
    URI: http://strathprints.strath.ac.uk/id/eprint/32631

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