Stanway, Susannah J and Purohit, Atul and Woo, L W Lawrence and Sufi, Saulat and Vigushin, David and Ward, Rebecca and Wilson, Richard H and Stanczyk, Frank Z and Dobbs, Nicola and Kulinskaya, Elena and Elliott, Moira and Potter, Barry V L and Reed, Michael J and Coombes, R Charles (2006) Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clinical Cancer Research, 12 (5). pp. 1585-92. ISSN 1078-0432
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties.
| Item type: | Article |
|---|---|
| ID code: | 32631 |
| Keywords: | androstenediol, breast neoplasms, coumarins, estradiol, estrone, neoplasm metastasis, neoplasms, sulfonamides, testosterone, Therapeutics. Pharmacology, Neoplasms. Tumors. Oncology (including Cancer) |
| Subjects: | Medicine > Therapeutics. Pharmacology Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer) |
| Department: | Strathclyde Business School > Accounting and Finance Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Pure Administrator |
| Date Deposited: | 19 Aug 2011 12:00 |
| Last modified: | 12 Mar 2012 11:31 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/32631 |
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